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Metabolic and adaptive response to different dietary intakes of copper. - AN0515

The systemic and intestinal adaptation to a low, a high and a customary dietary intake of copper will be characterised using stable isotopic labels in longitudinal studies in human volunteers. Simultaneously the effect of these intakes on the metabolism of lipids, fructose and glucose will be investigated to explore if fructose rich carbohydrate intakes interact with low copper intakes to exacerbate the risk of copper deprivation and to impair carbohydrate metabolism and insulin responsiveness.
To determinee copper requirements in adults with special reference to elucidating the interaction between reduced dietary copper supply and the systemic metabolism of fructose and glucose and of lipids.
Time-Scale and Cost
From: 1994

To: 1998

Cost: £287,370
Contractor / Funded Organisations
Central Science Laboratory