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The Role of Fatty Acids in Regulating Endothelial Cell Function and the Aetiology of Vascular Disease - AN0209

Determine the mechanisms at the cellular level by which different fatty acids, commonly found in the diet, can enhance or impair the function of human vascular endothelial cells in culture. Emphasis will be on the responsiveness of cells with different fatty acid compositions to various adverse haemodynamic, oxidative and immune-inflammatory stimuli. The novelty of this project is the correlation of physiological, pathophysiological and mechanical stimuli with the cells responses in relation to the multifactorial aetiology of vascular disease.
1. To determine how fatty acid modification of cell membrane lipids, in vitro or in vivo, influence the response of human umbilical vein endothelial cells(HUVEC) to haemodynamic and immune.inflammatory stimuli which may initiate vascular disease in man.
Time-Scale and Cost
From: 1993

To: 1996

Cost: £60,000
Contractor / Funded Organisations
Central Science Laboratory